They are saying you may’t preserve a superb man down, but comedian e book villains appear to be simply as profitable at staging a comeback. That can be the case this October, as one notably highly effective Spider-Man villain will defy demise to plague the universe. This may coincide with a landmark situation of Venom, that includes a workforce of all-star Marvel Comics creators.
The principle story of Venom #250 will focus on the return of Knull. Written by Al Ewing, with artwork by Terry Dodson, the story will discover Mary Jane Watson lastly moving into the swing of issues as the All-New Venom host. Sadly, Knull is out for revenge on the symbiote that just about destroyed him. And there can be no pleasant neighbor Spider-Man in sight to assist them!
Who’s Venom’s biggest enemy, Knull?

Often known as the god of symbiotes and Lord of the Abyss, Knull’s first full look got here in 2018’s Venom (Vol. 4) #3. Created by Donny Cates and Ryan Stegman, Knull instantly earned a spot amongst Marvel’s most feared supervillains. He headlined the 2020 King in Black occasion, going through heroes starting from Spider-Man to the Guardians of the Galaxy. He harbors a particular hatred for Venom, nonetheless, as he struck the killing blow when Earth’s heroes stood towards Knull.
“When Donny and Ryan introduced Knull into being, they created the first new villain shortly with what I’d name huge villain juice,” acknowledged Al Ewing. “He’s visually arresting. You understand what he needs in a single sentence. You may’t speak him out of it. He’s highly effective sufficient to carry down a crossover… and he was given the great luxurious of going away for some time. When an enormous unhealthy is allowed to lie fallow and drift into reminiscence, what’s remembered is all the issues readers preferred about them – and that’s when it’s time for a comeback.”
Venom #250 goes on sale at comic shops everywhere on October 1, 2025.